September 20, 2018

Fecal Transplant for Ulcerative Colitis effectiveness and safety in children and young adults

Here is more good news. A study was just released documenting the safety and effectiveness of Fecal Microbiota Transplant to treat Ulcerative Colitis in children and young adults (age 7 – 21.) Previous research and published case studies have consistently documented the safety and low prevalence of side-effects of fecal transplants primarily to treat Pseudomembranous Colitis caused by Clostridium Difficile bacteria, and to a lesser extent Ulcerative Colitis, however this is the first controlled study where fecal transplant was administered to children and young adults.

Fecal transplant which is also known by other terms including Fecal Microbiota Transplant (FMT), Fecal Bacteriothrapy, fecal enemas, stool transplant and Human Probiotic Infusion has also been used by others to treat Crohn’s Disease and Irritable Bowel Syndrome (IBS.)  Previous published information includes an article published by Dr. Borody in the Journal of Gastroenterology: Treatment of Ulcerative Colitis using Fecal Bacteriotherapy which documented the cases of 6 patients who have had permanent remission of symptoms ranging from 1 – 13 years after the conclusion of fecal transplants. Dr. Borody’s article was a strong reason that I decided to pursue this treatment option instead of surgery for Ulcerative Colitis.

As more information becomes known about the human microbiome, especially through the Human Microbiome Project (HMP) it is possible other illness might also be treatable or even permanently cured by altering the bacterial flora in certain areas of the human body.

Safety, Tolerability, and Clinical Response after Fecal Transplantation in Children and Young Adults with Ulcerative Colitis.

*Spectrum Health, Helen DeVos Children’s Hospital, Grand Rapids, MI, USA †Michigan State University, Grand Rapids, MI, USA ‡Emory University School of Medicine, Atlanta, GA, USA.

“Fecal Microbiota Transplant is being proposed as a novel treatment for UC… We initiated a pilot study to evaluate feasibility and safety of FMT in children with UC. Ten children, 7 to 21 years of age, with mild to moderate UC received freshly prepared fecal enemas daily for 5 days. No serious adverse events were noted… Fecal enemas were feasible and tolerated by children with UC. Adverse events were acceptable, self-limiting and manageable by subjects. FMT indicated efficacy in the treatment of UC…”

PMID:23542823 [PubMed – as supplied by publisher]

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